AFLATOXINAS Y SU ASOCIACIÓN CON EL DESARROLLO DE CARCINOMA HEPATOCELULAR

  • José Manuel Ornelas Aguirre
  • Adrián Fimbres Morales

Resumen

El carcinoma hepatocelular (CHC) se encuentra dentro de los tipos de cáncer que más muertes generan al año. Es una neoplasia con una incidencia creciente en todo el mundo. Es el tumor primario del hígado más frecuente y constituye el 90% de éstos. Se sabe que el desarrollo de CHC puede ser por múltiples etiologías, una de ellas es la exposición crónica a las aflatoxinas, especialmente a la aflatoxina B1 (AFB1), esta es una micotoxina producida por hongos del genero Aspergillus. La AFB1 produce mutación en el codón 249, exón 7 del gen P53. La AFB1 se encuentra en alimentos contaminados como granos de maíz, arroz y cacahuate, y se ha encontrado una alta relación entre el consumo de estos alimentos y el desarrollo de CHC en países de Asia y África. El presente trabajo tiene como objetivo recopilar la información existente sobre los mecanismos de carcinogenicidad de la AFB1 que lleva al desarrollo del CHC.

Palabras Clave: Carcinoma hepatocelular, Aflatoxina B1, Micotoxina, Aflatoxicosis

Citas

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